IV.9

Evaluating the 90 days and the next cycle

You have gathered ninety days of data — now it is time to read what it says. This week you read your own trend from your diary, decide with your doctor whether the remission is durable, and clarify whether another cycle is needed, or whether you can move towards maintenance.

Összefoglaló

At the start of the programme, the diary was still just an empty table. Now it holds ninety days of data — and this data tells a story about your recovery. This week you learn to read this story: how your daily stool count changed, whether the stool consistency normalised, whether the symptoms disappeared. From this, together with your doctor, the most important question can be answered: is the remission durable, or is another treatment cycle needed? The goal is not perfection, but a stable, symptom-free state — and deciding which way to go next. Whatever the result, the ninety days of data are the basis of the next good decision.

Read your own trend

The most telling fields of the diary are the stool count, the Bristol value and the presence or absence of symptoms. Look at the ninety days together, not just the individual days. It is a good sign of recovery if the daily stool count gradually decreased and stabilised, if the stool consistency shifted towards the normal, formed range (3 and 4 on the Bristol scale), and if the earlier symptoms — the cramps, the urgent need to defecate, the bloating — quietened and did not return.

Do not be alarmed by the occasional "swing": a worse day in itself does not mean relapse. The trend is what matters. If you were to draw a line across the ninety days, is the stool count trending downwards, and has the Bristol settled into the middle, healthy band? This is the real question.

The big question: is the remission durable?

Remission means that the symptoms of the infection have ceased, and durably stay away too. Ninety days is just enough time to judge this — but do not make the decision alone. Take your diary to your doctor, and review it together. If the trend is clearly good, you are symptom-free, and the stool is in order, then the remission is probably durable, and the emphasis shifts to maintenance and prevention.

If, on the other hand, the symptoms did not fully pass, or returned along the way, that is not a failure — it just means a decision has to be made about the next step. Another treatment cycle may be needed, perhaps with a different LOT or a different dose. Your diary is especially valuable here: it shows exactly where and when your condition tipped.

If another cycle comes

If your doctor recommends another cycle, it is the logical continuation of the road so far, not a step backwards. The programme is repeatable: you follow the same principles — classification, accurate capsule-taking, fluid replacement, lifestyle-building — only from an updated starting point. It is common that with a repeated course the preparation switches to a different LOT, so that the flora comes from a donor of a slightly different composition. Your job remains the same: follow your doctor's instructions, keep up the diary, and watch the red flags. The ninety days are not the end of something — they are a checkpoint from which you can consciously move on.

🩺 Klinikai blokk

The 90-day diary is built on the structure of the Compatibility Test Data xlsx, and the evaluation follows the G&E logic of the Compatibility Test Results / Patient Recommendation. The key indicators are: the trend of stool frequency, the normalisation of the Bristol distribution (target 3–4; Lewis & Heaton 1997 [357]), the presence/absence of bloody stool, and tolerability per LOT. The Clinical protocol guide v2.1 (May 2026) classifies a persistent Bristol 6–7 value after day 10 as an inadequate therapeutic response.

According to the DiffBiome datasheet, the taper is band-dependent: in the 25–39 SIS band it starts after day 10, in the 40–49 band from day 20, and in the 50–59 band from day 30. In the case of relapse, the protocol prescribes resuming the maximum dose, then continuing until the symptoms cease, after which switching to another LOT. Follow-up is recommended 1–2 weeks after the last dose. For a repeated relapse, v2.1 recommends another LOT; if the relapse occurs on the same LOT, a new FindBiome compatibility cycle may be started.

The logic of pathway reassignment is also guiding at the evaluation: in the case of a persistent SIS < 40, the patient may move onto the dysbiosis pathway (FindBiome compatibility bioassay → personalised TransferBiome, min. 60 days, 2–5 capsules/day). This is not a CDI relapse, but the targeted resolution of the background dysbiosis, and it is often precisely the 90-day evaluation that reveals the need for it.

Day 85 – Draw your trend

Today take out the whole diary and look at the ninety days as one. The goal is to see the direction, not the individual days.

  • Review the daily stool count from the first day until now: did it decrease and stabilise?
  • Look at the Bristol values: did they shift towards the 3–4, formed band?
  • Mark the worse days, and check whether there was a reason behind them (food, stress, medication)
  • Diary: today's usual fields + a short summary of the trend in the notes
Day 86 – Symptom inventory

Today take stock of your symptoms: what was there at the start, and what remains today?

  • List the initial symptoms (diarrhoea, cramp, urgent need, bloating), and mark which has passed
  • Estimate honestly: are you symptom-free now, or does something remain?
  • Prepare this inventory for the next medical consultation
  • Diary: the usual fields + the symptom inventory in the notes
Day 87 – Decision preparation with the doctor

Today summarise everything you read this week, and take it to your doctor: is the remission durable, or is another cycle coming?

  • Take the whole diary and the symptom inventory to the consultation
  • Ask the key question: based on the trend, can I move to maintenance, or is another cycle needed?
  • If another cycle comes, ask: which preparation, what dose, perhaps a different LOT?
  • Diary: the usual fields + the decisions of the consultation and the next steps

🍽️ Eating during these days

In the days of evaluating the 90 days, the role of eating is twofold: on the one hand, from the diary you read how your stool and symptoms developed alongside your diet, and on the other hand, you continue to feed the engrafted flora with the varied, fibre-rich diet that is the basis of durable remission. The concrete eating task for the three days: review which dietary habits proved their worth over the 90 days and are worth carrying on, keep up fluid replacement, and each day include the plant of the day in at least one meal.

For these days (85–87), the Plant Calendar (Appendix F) brings the sources turmeric (85), oregano / thyme (86) and broccoli sprouts (87). The polyphenols of turmeric and the herbs, and the sulforaphane of broccoli sprouts, increase plant diversity — and the herbs and sprouts also add to the weekly plant count, making the 30+ goal easier. In the second half of the programme (roughly days 61–90), the goal is to sustain full diversity and fermentable fibre sources: the more kinds of plant source that reach the plate, the more kinds of useful bacteria you feed, and the more short-chain fatty acids (including butyrate) form, which support the gut barrier and diversity. A diverse, stable flora is the basis of resilience — and it is precisely this durable balance that you are now evaluating at the close of the 90 days.

📊 Adat

For the evaluation, summarise these fields of the whole 90 days:

  • daily stool count — the trend of the whole period;
  • stool Bristol scale (1–7) — the distribution and the normalisation towards 3–4;
  • bloody stool (yes/no) — whether it occurred, when;
  • symptoms (cramp, urgent need, bloating) presence/absence over time;
  • DiffBiome dose and LOT — the progress of the course, the taper;
  • fluid intake, wellbeing (1–5) — general condition;
  • the worse days and their possible causes in the notes.
  • Movement: type + minutes, step count (target/actual)
  • Stress level (1–5) and mood (1–5)
  • Sleep (hours + quality 1–5)
Why does this matter?

The ninety days of data are not an end in themselves: they are what you and your doctor can use to make a well-founded decision. The trend shows whether your recovery is durable, or whether another step is needed — and whichever is the truth, it is not a failure, but information. Whoever knows their own trend does not guess, but decides. From here you either set off towards maintenance, or into a conscious, well-planned new cycle — both lead towards recovery.

[[REFERENCES]]

Tags

#Cdifficile #DiffBiome #értékelés #naplótrend #remisszió #következőciklus

References

[357] Lewis SJ, Heaton KW. Stool form scale as a useful guide to intestinal transit time. Scand J Gastroenterol. 1997. Link

The authors evaluated the responsiveness of the Bristol Stool Form Scale to changes in whole-gut transit time (WGTT). Sixty-six volunteers had WGTT measured with radiopaque markers and recorded stool form on a 7-point scale and defecation frequency; measurements were repeated under senna and loperamide. Baseline WGTT correlated with frequency (r=0.35, P=0.005) and stool output (r=-0.41, P=0.001), and best with stool form (r=-0.54, P<0.001). Senna (n=44) shortened WGTT and increased frequency, form score and output (all P<0.001); loperamide (n=43) lengthened WGTT and reduced frequency, form score and output (all P<0.001). The Bristol scale is a valid surrogate for intestinal transit time and is responsive to pharmacological alteration.

PG
DiffBiome Handbook · Authors: Dr. Patay Gábor — physician, microbiota specialist · Dr. Bezzegh Attila — medical director, clinical microbiologist · Dra. Anna Munar — physician, exposome specialist
MicroBiome Bank — medically reviewed professional content. Last updated: 2026.